Endocrine Abstracts

Introduction: The number of cells in tissue is governed by two processes – the proliferation and ‘programmed cell death’ – apoptosis. Both processes in the body are controlled by enabling or inhibiting factors that are expressed on the surface of CD25+ and CD95+-lymphocytes. Somatotropin (GH) and insulin-like growth factor 1 (IGF1) stimulate proliferation, differentiation, and division of immune cells simultaneously inhibits their apoptosis and can cause tu...

Introduction: Somatotropin (GH) and insulin-like growth factor 1 (IGF1) realize their influence on the system of intracellular metabolism and a number of important biochemical lymphocytes reactions through the receptor apparatus. It is allows to use the peripheral blood lymphocytes as the investigations object of intracellular metabolism disorders in acromegaly.Aim: To study the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in pati...

The chronic GH and IGF1 excess causes a specific changes in immune system due to presence of its receptors on T-, B-lymphocytes, granulocytes. The aim of this study was to evaluate the subpopulation composition and chemiluminescence’s indices of neutrophils in patients with active acromegaly.Thirty-three patients with active acromegaly (11 men and 22 women, mean age 51.7±11.7 years) and 53 healthy subjects sex- and age-matched with the patients...

GH and IGF1 regulate plastic and synthetic intracellular lymphocytes process. We aimed to investigate the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in patients with active acromegaly.Thirty-three patients (11 men and 22 women, mean age 51.7±11.7 years), with the 6–10 years active phase duration of acromegaly, and 53 age- and gender matched healthy controls were determined the activity of NAD(P)-dependent dehydrogenase...